Fertile PLUS ™ is a research formulated proprietary mix of essential minerals and highly bioavailable vitamins and antioxidants that work together to protect both men and women’s overall reproductive wellness from vitamin deficiencies and reducing free radical damage.


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"Preconception" Formula:

Dr. Fertility's preconception formula is taken prior to conception to enhance egg, embryo and sperm quality and best prepare our body for full fertility potential.The generation and maturation of sperm and ovum that form an embryo takes a period of 120 days; and everything that you and your partner ingest, inhale or are exposed to will influence the health of your eggs and sperm and the ultimate quality of the genetic building blocks you pass onto your child. This is why it's crucial to follow a good preconception plan for a minimum of 4-6 months before conception.

Antioxidants are the first line of defense for your cells from the damage caused by free radicals. Whether it's due to normal cellular metabolism, exposure to pollution and toxins, stress, or poor diet and lifestyle, the body's cells are constantly facing oxidative stress from free radicals, which attack your cells up to 10,000 times a day. Antioxidants neutralize the activity of free radicals, protecting the cells of your reproductive organs that create ovum/egg and sperm; and the glands that produce important reproductive hormones.

Minerals are fuel for your body. Without adequate amount of minerals, vitamins, and trace elements, your body would be unable to function. These essential nutrients help regulate body chemistry, build strong teeth and bones, efficiently metabolize nutrients, and support antioxidants. Fertile PLUS provides a balance blend of these essential and ultra trace minerals, each of which play many roles in the body.

Vitamin C:

Helping to reduce the chance of miscarriage and chromosomal problems.

Vitamin C improves hormone levels and increases fertility in women with luteal phase defect, according to a new study published in Fertility and Sterility (2003;80:459-61).

Women who have total vitamin C intakes of 10th percentile preconceptionally have twice the risk of preterm delivery because of premature rupture of the membranes. *7

As for men, vitamin C has been shown to improve sperm quality and protect sperm from DNA damage; Vitamin C also appears to keep sperm from clumping together, making them more motile.

Strengthens collagen and support healthy tissue growth, promoting healthy veins and arteries. *6

Vitamin E:

Vitamin E stabilizes and protects the cell membrane from toxic compounds (lead, mercury and other heavy metals), toxic compounds (benzene, cleaning solvents) and free-radicals. This is especially important for hormonal balance, as well as cellular health. Toxic compounds have been shown to contribute to infertility.

Vitamin E scientific word, tocopherol in Greek, means "to bear young" from 1922 studies on infertile rats that were vitamin E deficient and fertility was restored once vitamin E was replenished.

Studies have shown that vitamin E increases sperm health and motility. In one study it was shown that sperm motility, percent of live sperm, and percent of normal spermatozoa all increased with the supplementation of vitamin E and selenium.

Vitamin E and selenium can also improve sperm motility. One study published in the Archives of Andrology confirmed the protective and beneficial effects of vitamin E and selenium on semen quality, and supported their use in male infertility treatment.

Studies show men who prepared with vitamin E prior to IVF treatment with their partners had an increase in rate of fertilization from 19% to 29%.

Inositol

Myo-inositol is a member of the vitamin B-complex group.

Myo-inositol has been used in the treatment of diabetic neuropathy, and polycystic ovary syndrome (PCOS).

In women with PCOS, myo-inositol improves insulin sensitivity and reduces insulin levels.

In patient with PCOS, a high percentage of women taking myo-inositol will establish regular periods and show evidence of ovulation

Myo-inositol's can be beneficial in improving fertility because of its effectiveness in women with PCOS, in vitro fertilization (IVF) procedures and pregnancy.

Vitamin K

Highly bioavailable form that's much better absorbed by the body. Helps with blood coagulation and inhibition of arterial calcification *5

FERTILITY APPROVED 

Super Antioxidants

Supplementing your diet with Fertile PLUS will provide the essential vitamins and minerals your body needs in maintaining and developing healthy eggs and sperm.

CoQ10:

Supports production of cellular energy for muscles and the heart, for which demand is especially high, making this an important nutrient for cardiovascular health. *3

Supports production of cellular energy for egg and sperm, for which mitochondria demand is especially high, making this an important nutrient for reproductive and fertility health

High follicular fluid CoQ10 level is associated with optimal embryo morphokinetic parameters and higher pregnancy rates. *4

A study in Fertility and Sterility shared that CoQ10 helped to increase the sperm motility in semen in select individuals.

Vitamin D:

Among women of reproductive age, more than 40% are insufficient in vitamin D

Women with higher vitamin D levels were significantly, 4 times in one study, more likely to achieve pregnancy from IVF compared to women with deficient or depleted levels of vitamin D

Vitamin D impacts fertility on multiple levels, including boosting levels of progesterone and estrogen in women, which may help regulate menstrual cycles and improve your likelihood of conceiving naturally

In men, vitamin D is essential for the healthy development of the nucleus of the sperm cell, improves semen quality and sperm count, and is capable of supporting healthy testosterone levels

L-Arginine

L-arginine is thought to improve the reproductive health of both men and women because:

It increases blood circulation to the uterus, ovaries and genitals - increased blood flow can improve reproductive health. L-arginine allows for better blood circulation to the ovaries, allowing for optimum egg production. The increased blood flow to the uterus also creates a better environment to allow the implantation of a fertilized egg. Blood flow is important for the proper functioning of the reproductive organs, and may improve the chances of conception.

It increases Nitric Oxide levels - L-arginine is used by the body to create Nitric Oxide (NO). Research has found that increased NO levels supports healthy inflammation levels which may help to prevent uterine fertility issues such as fibroids, endometriosis and PCOS. Inflammation is a contributing factor to a number of fertility issues shown to negatively impact conception and implantation.

Supports normal sperm production-research has found that taking a l-arginine supplement daily can increase sperm production in men. In the study, the effects were noticeable 6-8 weeks from the start of supplementation. L-arginine may also improve the motility of sperm, thus increasing the chance of conception in couples suffering from low sperm motility. Where IVF is used, l-arginine can be used to improve the quality of sperm, increasing the chance of achieving a fertilized egg.

Improve the production of cervical mucous - the increased blood flow to the reproductive organs can aid in the production of cervical mucous. Abnormal mucous production contributes to the challenges faced by around 1 in 20 women dealing with fertility issues. Some women do not produce enough cervical mucous, and others produce a mucous that is too thick for sperm to travel through. L-arginine can encourage better production of cervical mucous through improved blood flow.

Supports a healthy libido-L-arginine increases blood flow to the genitals in both men and women, leading to an increased libido. In men, increased blood flow to the penis can result in more frequent and sustained erections. L-arginine is often suggested for men suffering from erectile dysfunction. In women, increased blood flow to the genitals can lead to increased sexual arousal and orgasm. A healthy libido plays an important role in conception.

B12

Men who are deficient in vitamin B12 can also suffer from poor motility (where the sperm don't swim very well) so it is thought that taking this vitamin may be helpful as well.

Vitamin B6, B12, D, Thiamin & Folate

Essential for producing and supporting healthy immune cells, these antioxidants help protect the body against stress. *6,8,10

Safe for Use During IVF Protocol

Fertile Plus™ does not contain any herbs that could interfere with medications or other aspects of an IVF cycle, it can be used safely throughout in-vitro fertilization (IVF) and intrauterine insemination (IUI) protocols.

References:

1 Shah Prakesh, Ohlsson Arne,. et al. "Effects of prenatal multimicronutrient supplementation on pregnancy outcomes: a meta-analysis." 2009. CMAJ. 180(12): doi: 10.1503/cmaj.081777.

2 Lisa M. Bodnar, Gong Tang, Roberta B. Ness, Gail Harger, James M. Roberts; Periconceptional Multivitamin Use Reduces the Risk of Preeclampsia. Am J Epidemiol 2006; 164 (5): 470-477. doi: 10.1093/aje/kwj218.

3 Kaikkonen J, Tuomainen TP, Nyyssonen K, Salonen JT. "Coenzyme Q10: absorption, antioxidative properties, determinants, and plasma levels." 2002. Free Radic Res 36(4): 389-97.

4 Akarsu, S., Gode, F., et al. "The association between coenzyme Q10 concentrations in follicular fluid with embryo morphokinetics and pregnancy rate in assisted reproductive techniques." 2017. J Assist Reprod Genet. [Epub ahead of print]. doi: 10.1007/s10815-017-0882-x.

5 Geleijnse, J.M., Vermeer, C., et al. "Dietary intake of vitamin K-2 reduces the risk of cardiac event and aortic atherosclerosis: The Rotterdam Study." 2004. J Nutr. 134:3100-3105

6 Beveridge S, Wintergerst ES, et al. "Immune-enhancing role of vitamin C and zinc and effect on clinical conditions." 2008. Proc Nutr Soc 67:E83

7 Siega-Riz A, Promislow J, et al. "Vitamin C intake and the risk of preterm delivery." 2003. AJOG. 189(2):519-525.

8 Wang T, Pencina M, et al. "Vitamin D Deficiency and Risk of Cardiovascular Disease." 2008. Circulation. 117(4):503-11.

9 McGrath J, Feron F, et al. "Vitamin D3—implications for brain development." 2004. Journal of Steroid Biochemistry and Molecular Biology. 89-90:557-560.

10 Cui R, Iso H, et al. "Deitary Folate and Vitamin B6 and B12 Intake in Relation to Mortality from Cardiovascular Diseases- Japan Collaborative Cohort Study." 2010. 41:1285-9.

11 Haider B, Ibironke O, et al. "Anemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis." 2013. BMJ. 346. f3443.

Vitamin D References:

References for Vitamin D and Fertility

Michaelsson, K; Baron, JA; Snellman, G; Gedeborg, R; Byberg, L; Sundstrom, J; Berglund, L; Arnlov, J et al. Plasma vitamin D and mortality in older men, a community-based prospective cohort study. The American Journal of Clinical Nutrition, 2010;92(4):841-8.

Kinuta K, Tanaka H, Moriwake T, Aya K, Kato S, Seino Y. Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinology, 2000;141:1317-24.

Yoshizawa T, Handa Y, Uematsu Y, Takeda S, Sekine K, Yoshihara Y, et al. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet, 1997;16:391-6.

Halloran BP, DeLuca HF. Effect of vitamin D deficiency on fertility and reproductive capacity in the female rat. J Nutr, 1980;110:1573-80.

Kwiecinski GG, Petrie GI, DeLuca HF. Vitamin D is necessary for reproductive functions of the male rat. J Nutr, 1989;119:741-4.

Johnson LE, DeLuca HF. Vitamin D receptor null mutant mice fed high levels of calcium are fertile. J Nutr 2001;131:1787-91.

Vigano P, Lattuada D, Mangioni S, Ermellino L, Vignali M, Caporizzo E, Panina-Bordignon P, Besozzi M, Di Blasio AM. Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. J Mol Endocrinol, 2006;36(3):415-24.

Vigano P, Lattuada D, Mangioni S, Ermellino L, Vignali M, Caporizzo E, Panina-Bordignon P, Besozzi M, Di Blasio AM. Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. J Mol Endocrinol, 2006;36(3):415-24.

Bodnar LM, Catov JM, Simhan HN, Holick MF, Powers RW, Roberts JM. Maternal vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab, 2007;92(9):3517-22.

Ozkan S, Jindal S, Greenseid K, Shu J, Zeitlian G, Hickmon C, Pal L. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertility and Sterility, 2010;94(4):1314-9.

Rudick B, Ingles SA, Stanczyk F, Chung K, Paulson R, Bendikson K. Characterizing the role of vitamin D levels on IVF outcomes: stimulation, embryo, or endometrium? O-245, Annual Meeting of the American Society for Reproductive Medicine, 2010.

Rudick B, Ingles SA, Stanczyk F, Chung K, Paulson R, Bendikson K. The role of vitamin D levels on IVF outcomes in donor-recipient cycles. O-9, Annual Meeting of the Pacific Coast Reproductive Society, 2011.

Recommended Use: Take six (6) capsules daily. For best results, take three (3) capsules two times daily (total six), preferably with food in the AM & PM or as recommended by your health care professional.

Serving Size: 6 Capsules
Serving Per Container: 180

Supplements Fact

Amount Per Serving % Daily Value
Vitamin A (as beta-carotene) 5,000 IU 100%
Vitamin C (as calcium ascorbate and magnesium ascorbate) 1,000 mg 1,667%
Vitamin D (as cholecalciferol) 2,000 IU 500%
Vitamin E (as d-alpha- tocopheryl succinate) 400 IU 1,333%
Vitamin K (as menaquinone-7) 80 mcg 100%
Thiamin (as thiamin HCl) 27 mg 1,800%
Riboflavin 27 mg 1,588%
Niacin (as niacinamide & niacin) 40 mg 200%
Vitamin B6 (as pyridoxal 5-phosphate) 32 mg 1,600%
Folate [as (6S)-5- methyltetrahydrofolic acid, glucosamine salt)] 1,000 mcg 250%
Vitamin B 12 (as methylcobalamin) 200 mcg 3,333%
Biotin 300 mcg 100%
Pantothenic acid (as D-calcium pantothenate) 90 mg 900%
Calcium 150 mg 15%
Iron (as ferrous fumarate) 28 mg 156%
Iodine (as potassium iodide) 300 mcg 200%
Magnesium (as magnesium citrate, magnesium amino acid chelate & magnesium ascorbate) 100 mg 25%
Zinc (as zinc picolinate) 20 mg 133%
Selenium (as selenium amino acid chelate) 200 mcg 286%
Copper (as copper bisglycinate chelate) 2 mg 100%
Manganese (as manganese gluconate) 5 mg 250%
Chromium (as chromium picolinate) 300 mcg 250%
Molybdenum (as molybdenum citrate) 40 mcg 53%
N-Acety- L-cysteine 600 mg *
L-Arginine HCl 500 mg *
Inositol 150 mg *
Coenzyme Q10 (Ubidecarenone) 50 mg *
Boron (as boron citrate) 3 mg *
* Daily value not established.

Other Ingredients: Hypromellose, magnesium stearate, stearic acid, calcium citrate and silica.

WARNING:Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of the reach of children. In case of accidental overdose, call a doctor or poison control center immediately.

Important: If you have pre-existing medical condition, consult a doctor before use. Do not use if printed seal is broken or missing.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.


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